Italian prosecutors have filed an appeal against the October acquittal of American student Amanda Knox on Tuesday.

Prosecutors Giovanni Galati and Giancarlo Costagliola filed the motion arguing that Knox's acquittal for the death of her British roommate Meredith Kercher was "contradictory and illogical."

Galati told reporters in Perugia that the appeals decision, which threw out the original conviction, was wrought with "omissions and many errors."

The 112-page appeal will be reviewed by the Court of Cassation, which will determine if there are grounds for retrial.

The Knox family released a statement on Tuesday calling the motion "simply another example of harassment by the prosecution against Amanda."

Meredith Kercher, 21, was found dead on Nov. 1, 2007 in the Perugia apartment she shared with the Seattle-native Amanda Knox.

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In a 2007 murder trial, Knox was convicted alongside her then Italian boyfriend Raffaele Sollecito for the murder of Kercher in what the prosecution described as a drug fueled orgy gone wrong. A third man, Rudy Guede was also convicted in a separate trial for the murder.

Knox and Sollecito were acquitted in a highly publicized appeals trial in 2011.

In an official statement regarding the acquittal the Italian court said that there was a "material non-existence" of evidence to convict Knox and Sollecito. The court additionally found the prosecution's description of the murder as a drug fueled orgy gone wrong as "far from probable."

The Kercher family continues to believe that both Knox and Sollecito know what happened the night their daughter was murdered and have always said that they backed the original verdict in the Amanda Knox case.

Kercher's father has called the acquittal "ludicrous."

"There were 47 wounds on Meredith and two knives used. One person couldn't possibly have done that," he told the Daily Mirror in October.