Arsenal will travel to Germany to face a FC Schalke team that thoroughly defeated the Gunners during the pair's first meeting in the group stage of the Champions League.
Arsenal manager Arsene Wenger will be tasked with preparing his team after they were convincingly defeated at home in their last Champions League match.
The 2-0 defeat at the Emirates snapped the Gunners 45-game unbeaten match streak at home against foreign clubs and shook up Group B. Arsenal is currently in second place in the group behind Schalke and a positive result would go a long way in securing a knock-out round birth.
Wenger will have his work cut out for him given that he will have a few key players unavailable due to injury. Alex Oxlade-Chamberlain, Gervinho, Kieran Gibbs and Abou Diaby will be watching the match from the bench.
History is not on the English club's side, as Arsenal has won just seven of their previous 24 games against German opponents, while Schalke has proven to be a solid team in European competitions, losing just four of their last 25 European matches.
Schalke manager Hubertus Stevens will be looking to widen his team's lead in Group B as the Royal Blues currently have a 1-point edge over the Gunners.
Will a full three points on Tuesday, the lead would be stretched to four, with two matches to go, and would all but assure Schalke a spot in the next round.
Stevens will have to start with a strong defensive formation as to not give away easy points to Arsenal as they did when the teams met for the first time.
Arsenal dominated possession in the first match, but was not able to generate any dangerous chances because of the German side's tight and organized back line.
Kickoff for the match is at 2:45 and can be watched online here.