Chelsea Handler ended her relationship with rapper 50 Cent after one of his former girlfriends appeared on her late night television show, the comedienne told E! Online.
Rumors of Handler's relationship with the rapper began in 2010 when they were caught by photographers enjoying an evening out together, but both denied the speculation.
Handler, 36, finally confirmed she was dating the hip hop star last year in an interview with CNN's Piers Morgan, but the odd couple's relationship ended shortly after.
"We dated for a couple months and then we had a falling out. One of his ex-girlfriends was coming onto my show," Handler told E! Online. "He called to warn me and I was like, at my job. It was just so juvenile. I was at work. I hung up and I've never spoken to him again."
"I do think he's a really nice guy and I think he's smart in a certain way," Handler added.
According to the "Chelsea Lately" host, the Grammy-winning rapper was also popular with her girlfriends, actress' Jennifer Aniston and Reese Witherspoon.
"My friends all loved him, my friends fell in love with him. They loved that I was dating him. They were like, 'Chelsea, come on.' They were both laughing really hard at it... I mean, everyone was."
Handler will co-star in the upcoming comedy "This means War" with Witherspoon.
Handler also admitted to dating hotelier Andre Balazs on an April 2011 episode of her show, but later said that she would respect their relationship and not discuss too much of it because Balazs has children.
The comedienne turned actress is also the author of four New York Times best sellers, including her memoir, My Horizontal Life: A Collection of One-Night Stands and a humorous book of essays entitled Are You There, Vodka? It's Me, Chelsea.