Chelsea will make the trip to Craven Cottage to face Fulham F.C. as the Blues continue to fight for a top four finish in the league.
Chelsea and manager Rafael Benitez will be looking to bounce back after they were eliminated from the FA Cup at the hands of Manchester City.
Chelsea are expected to play captain John Terry and midfielder Frank Lampard, who were left out of the FA Cup defeat at the hands of City at Wembley.
Benitez is also expected to rotate his squad once again for this west London derby as Chelsea navigates their packed match schedule.
Striker Fernando Torres could also start in a week, which will end with him playing his former club Liverpool this weekend, as Demba Ba continues to find his form since recovering from an ankle injury.
Chelsea will also have to contend with the absence of defenders Ashley Cole and fellow England defender Gary Cahill. Long-term absentee Oriol Romeu will remain off the substitutes list and Marko Marin is still doubtful to see any action.
For Fulham and manager Martin Jol, they will be concerned with finishing the season on a high note as they are currently 10th in the league and are almost certain to remain in the top flight unless they fall victim to and end of the season collapse.
Fulham will have to contend with the absence of Damien Duff, who will miss the match with his former club due to an injury.
The 34-year-old was forced off after 10 minutes into Saturday's 1-1 draw with Aston Villa with an adductor strain. The injury will also likely cause him to miss this weekend's match against Arsenal.
Former Chelsea midfielder Steve Sidwell will also miss the match die to suspension, and Ashkan Dejagah and Mahamadou Diarra are sidelined for the remainder of the season with injury.
Kick-off for the match is at 3:00 p.m. ET and can be watched online here.