Ecuador plays host to Argentina at Estadio Olimpico Atahualpa in Quito in the latest fixture for World Cup qualifying.
Argentina will be looking to secure a full three points from Ecuador after being held to a 0-0 draw against Colombia in Buenos Aires on Friday night.
Alejandro Sabella's men know heading into this match they would almost be guaranteed a spot in Brazil should they earn a full three points, but that task will be difficult with several starters out due to suspension and the fact that Ecuador has a perfect home record thus far in qualification.
Gonzalo Higuain and Pablo Zabaleta will be unavailable after the pair is suspended while Lionel Messi may come off the bench as he continues to recover from injury.
It is thought that Argentina will likely repeat the same 5-3-2 formation used when La Albiceleste visited Bolivia in March. Jose Basanta should be a fixture in the middle of the defense.
In attack, Sergio Aguero is likely to be partnered by Rodrigo Palacio, with Angel Di Maria in a supporting midfield role. Ezequiel Lavezzi is also an option to play on the attacking line should the situation present itself.
The match should be a focused on defense as Argentina has conceded only eight goals in their last 12 matches while Ecuador have won all six of their home fixtures in qualification. Ecuador, however, has scored in 13 of their 16 goals in the competition on home soil.
The most significant change from Ecuador will see Felipe Caicedo regain his place in the starting lineup. The striker was a fitness doubt in the loss to Peru thanks to a muscle strain, but appeared in the second half of that fixture and is expected to partner Christian Benitez up front.
Kick off for the match is at 6 p.m. ET and can be watched online here.