Manchester City will host Viktoria Plzen at the Etihad Stadium on Wednesday and will be playing for the top spot in Group D.
While Manuel Pellegrini's side has already earned place in the Champions League knockout stages, after two seasons of early exits, they will still look to continue their good form against the Czech club.
With a rapid fan base eager for City to progress on to the Round of 16 the fact that the Manchester club has done so with two games to spare shows a focus within the club that was lacking under Roberto Mancini last season.
One of the more notable consequences resulting from this tie will be the question regarding who finishes first and second in Group D: he winner of the group will possibly face a slightly easier foe in the next round.
Defending champion Bayern Munich currently tops the group but City is just three points off the pace and will travel to the Allianz Arena on Matchday Six.
Victory over Viktoria Plzen, who remains pointless in the group, would keep finishing in the top spot a possibility, but the Czech visitors will be looking to salvage their pride from this competition.
Plzen, who won the Gambrinus liga (Czech Republic) last season and qualified for the Champions League over the summer, has been less than stellar in their first four matches, losing every match while managing to score a pathetic two goals while conceding 12.
Still, before losing 3-0 to City in the pair's first meeting, they held City for 48 minutes and played as their equals.
Plzen understands that earing points in the match would keep their hopes alive to play in the Europa League by taking that spot currently held by CSKA Moscow – a team they will face in December.
Kickoff for the match is at 2:45 p.m. ET and can be watched online here.