Manchester United travel to the Madejski Stadium to face a Reading side looking for points in their quest to move out of the relegation area at the bottom of the table.
Manchester United and manager Sir Alex Ferguson look to increase their lead in the Premier League and continue in their stellar form, but will have to do so without Nani and Antonio Valencia.
Nani is slated to miss up to five weeks with a hamstring injury while Ecuadorian international Antonio Valencia continues to have problems recovering from a hip injury.
On a positive note Paul Scholes will be available after serving his suspension as well as Ryan Giggs who passed a fitness test after tweaking his hamstring.
Manchester United begins December at the top of the Premier League for the sixth time. The club has gone on to win the Premiership on four of the previous five occasions they led the league entering the month.
They are one point clear of defending champions Manchester City and seven ahead of Chelsea.
United are in top form having won five away games with their last away loss coming at the hands of Norwich City.
Reading and manager Brian McDermott are at the other end of the spectrum sitting one spot above last place Queens Park Rangers.
Reading has managed only one win so far this season to go along with six defeats and six draws. Earning zero points in their last two matches, Reading are currently four points away from being clear of the relegation line, but McDermott is confident his side can come through and stay in the Premier League.
"We have to stick together now … it is really important we do that as a group, as fans," McDermott told reporters during a press conference.
"Hopefully they will stick with us, and get us over the line, and we get a result somewhere. We've got Manchester United next and it doesn't get any better," he added.
Kick-off for the match is at 12:30 p.m. ET and can be watched online here.