Stoke City will make the trip to Old Trafford where David Moyes' men earned a 1-0 win over Real Sociedad in the Champions League on Wednesday night.
The Red Devils are in eighth place in the Premier League and have lost three of their opening eight league games.
Stoke boss Mark Hughes claims United are vulnerable and can ill afford any missteps should they still hope for a top four finish. However, the Potters have not had the best run as of late, having failed to find the net in their last three matches, losing to Norwich and Fulham and playing West Brom to a goalless draw.
History is on the side of United given they have won all five of their previous Premier League home games against Stoke.
City, meanwhile, have lost more Premier League games against United than versus any other side, losing a total of nine. United fans should rest a little easier given that Robin van Persie is set to return for the match against Stoke.
The Dutch striker missed the Champions League win over Real Sociedad and could partner with Wayne Rooney on the attacking line. Danny Welbeck and Tom Cleverley are doubtful as they both continue to recover from their respective injuries.
Stoke captain Ryan Shawcross and defender Geoff Cameron are Stoke's major doubts ahead of Saturday's trip to Manchester United. Shawcross has not trained all week due to illness and Cameron missed last week's draw with West Brom after picking up a calf injury.
Mark Hughes' side have only scored four goals so far this season and Stoke have not won at Old Trafford since 1976.
Kick off for the match is at 10:00 a.m. ET and can be watched online here.