Premier League leaders Manchester United hosts West Ham United and will be looking to increase their lead in the Premiership.
For United boss Sir Alex Ferguson, he will be hoping his side keeps their focus after having early trouble against last place Queens Park Rangers.
Goalkeeper Anders Lindegaard expressed his own concern for United's falling behind in games this season, even though his team came back during Saturday's 3-1 win over QPR; Jamie Mackie had put the last place club on top early in the second half.
That seemed to awaken a sleeping giant as United scored three goals in about eight minutes and were able to secure the teams 10 league win of the season, but it was the ninth time the Red Devils had to come from behind to win in all competitions.
Even during United's last match against West Ham they had to overcome a 2-0 half-time deficit. They did and were able to win 4-2 at Upton Park after Wayne Rooney's hat-trick.
Rooney has been in top form as of late and has scored seven goals in his last four games against the Hammers while Robin van Persie has scored four goals in his last four starts against the west London club.
To add to United's offensive prowess, they have Javier Hernandez in peak form, with the Mexican international scoring eight goals in his last eight games. United is playing for their eighth straight win over West Ham.
For West Ham and manager Sam Allardyce, they will be looking to regain the points they lost after being defeated 3-1 at Tottenham on Sunday.
New West Ham man Andy Carroll scored his first goal for the club on Sunday and will be looking to cause confusion for a United defense that has only produced two clean sheets in the Premier League this season.
Kick-off for the match is at 3:00 ET and can be watched online here.