The NFL and the Grand Ole Opry will feature Mandisa for their Breast Cancer Awareness month where she will kickoff performing the national anthem during this Sunday night NFL Network game.
The game will be a match up with the 49ers and Texans (7:30 PM CT, NBC).
While Mandisa is singing, survivors of Breast Cancer will join the singer on stage.
The NFL and NFL Players Association are supporting National Breast Cancer Awareness Month with their fifth annual screening initiative, "A Crucial Catch: Annual Screening Saves Lives," and a fundraising campaign. The initiative reminds women 40 and older about the importance of having an annual mammogram.
The Grand Ole Opry also asked Mandisa to unit with them on Tuesday, Oct. 22, for Women Rock For The Cure to battle breast cancer at the fifth annual "Opry Goes Pink" show.
LeAnn Rimes will take part in the festivities as well s numerous other artists.
Mandisa, was recently on Fox & Friends to help celebrate new co-host, Elisabeth Hasselbeck's first day.
Mandisa's music video for "Overcomer" debuted two weeks ago exclusively on Good Morning America's website.
The video features appearances with former U.S. Congresswoman Gabby Giffords, Captain Mark Kelly, Gold Medalist Scott Hamilton, and GMA's Robin Roberts.
"We chose each of them because when we thought of who has been an example of an overcomer in a very public battle, it is hard to imagine anyone more appropriate than the amazing people in my video. They have all fought, and continue to fight victoriously. I pray that sharing their inspirational stories throughout the video will leave people saying, 'If they can do it, so can I!'" Mandisa said in a press release.
"I was really inspired by Mandisa's song 'Overcomer' because its message is one of hope, perseverance and faith," said Gabby Giffords, former U.S. Congresswoman about the song in a statement. "We can't always control what happens to us in life, but we can control how we respond. Like the song says, if we keep positive and 'stay in the fight till the final round,' we can overcome more than we ever dreamed possible."
The single was originally performed on "Good Morning America" Thursday, Aug. 29, and since then the song has peaked at no. 1 on the iTunes Christian Singles Chart and is no. 1 on AC Indicator.