The debate at Longwood University in Farmville, Virginia, was lively from the start as Kaine, the running mate of Democratic presidential nominee Hillary Clinton, honed in on Trump's refusal thus far to reveal his tax records, saying he had broken a promise to do so.
Indiana Governor Mike Pence, the Republican nominee for U.S. vice president, lost another round in federal court on Monday in his bid to keep refugees fleeing Syria's civil war from resettling in his state.
At least one person was killed and scores injured, some critically, when a commuter train ploughed into Hoboken station in New Jersey during the morning rush hour on Thursday, officials said.
A 14-year-old boy is believed to have shot and killed his father before going to a nearby elementary school in South Carolina and wounding two children and a teacher on Wednesday afternoon, authorities said.
The U.S. Senate overwhelmingly rejected on Wednesday President Barack Obama's veto of legislation allowing relatives of the victims of the Sept. 11 attacks to sue Saudi Arabia's government.
Former Israeli president and elder statesman Shimon Peres died in Tel Aviv on Wednesday aged 93, according to media reports.
Democrat Hillary Clinton accused Republican Donald Trump on Monday of having a long history of racist behaviour during a heated presidential debate that could reshape the 2016 campaign for the White House.
Democrat Hillary Clinton and Republican Donald Trump will face off for the first time on Monday in a presidential debate that could rank as one of the most watched, highly anticipated political showdowns in U.S. history.
African American History Museum Opens With Ringing of Freedom Bell From Historic First Baptist Church (Photos)
President Barack Obama on Saturday expressed hope that a new national museum showcasing the triumphs and tragedies of the African American experience will help to bring people together as the nation reels from recent racial upheaval.
Five potential bombs were discovered overnight near a New Jersey station, one of which blew up on Monday as a bomb squad robot tried to disable it, after a weekend of attacks and security alerts in the United States.
An explosion rocked the bustling Chelsea district of Manhattan on Saturday night, injuring at least 29 people in what authorities described as a deliberate, criminal act, while saying investigators had found no evidence of a "terror connection."
Two bombs killed at least 13 people and wounded dozens outside a court complex in northwest Pakistan on Friday, a rescue official said, hours after militants killed two people in a Christian neighborhood in the same region.
Twelve people, including seven students, were killed in an attack on the American University in Kabul that sent hundreds of students fleeing in panic, police said early on Thursday, before the assault ended when two gunmen were shot dead.
The number of people killed in the earthquake that devastated parts of central Italy on Wednesday rose to 247 on Thursday morning, regional and national officials said.
Fifty-one people were killed and 94 wounded when a suspected suicide bomber targeted a wedding celebration in the Turkish city of Gaziantep on Saturday, adding to a surge in violence this week in the mainly Kurdish southeast.
U.S. Republican presidential candidate Donald Trump toured flood-battered Louisiana on Friday, shrugging off the Democratic state governor's plea for politicians not to stop in areas affected by deadly rains.
U.S. Olympic gold medallist swimmer Ryan Lochte issued an apology on Friday and his teammate Jimmy Feigen agreed to pay 35,000 reais (8,420 pounds) to a charity after Brazilian police said they lied about being robbed at gunpoint at the weekend.
Anti-American sentiment among Turks is on the rise and can only be calmed by the United States extraditing the Muslim cleric Ankara accuses of orchestrating last month's failed coup, Turkey's justice minister said on Tuesday.
A suicide bomber in Pakistan killed at least 63 people and wounded dozens more in an attack on mourners gathered at a hospital in Quetta, according to officials in the violence-plagued southwestern province of Baluchistan.
One woman was killed and five others injured by a man with suspected mental health issues who went on the rampage with a knife in central London, an attack police said could be linked to terrorism.
Pope Francis Says Catholic Church Might Give Women Right to Be Ordained Ministers, as Deacons Not Priests
Pope Francis has set up a commission to study the role of women deacons in early Christianity, the Vatican said on Tuesday, a move that might lead to changes in the role of women in the Roman Catholic Church.
A San Diego police officer was fatally shot and another was wounded on Thursday during a traffic stop as a suspect was taken in custody, local media reported and the department said on social media.
Former Secretary of State Hillary Clinton secured the Democratic Party's 2016 nomination for the White House on Tuesday, becoming the first woman to head the ticket of a major party in U.S. history.
A 27-year-old Syrian man denied asylum in Germany a year ago blew himself up on Sunday outside a crowded music festival, injuring 12 people in the country's fourth violent attack on members of the public in less than a week.
At least two people were killed and more than a dozen others, many of them teenagers, were wounded in a shooting early on Monday outside a Florida nightclub that was hosting a party for all age groups, authorities said.