Hruz also said that it's well established that hormones play a vital role in skeletal development. He noted that there is concern that people who take puberty blockers may be at risk of Osteoporosis later in life.
Hruz stressed that an undoubted consequence of suppressing puberty and then treating children with cross-sex hormones is that it renders them infertile.
"When you follow up pubertal blockade with cross-sex hormones it's generally accepted that this is going to be irreversible," he explained. "Again, we are talking about children, children who ... are in the process of exploring and developing [their sexuality] and they are being made infertile at a time when they are making these decisions at these ages."
Cretella warned that gender clinics tell parents of children struggling with gender dysphoria that they "must" transition their child or else they will "grow up to commit suicide." However, such treatment is not Food and Drug Administration approved, she said.
"What the experts don't share with the family is this is an off-label use, it's not FDA-approved," Cretella said of the puberty-blocking drug Lupron.
When Lupron is used to treat prostate cancer in adult men, it is associated with memory problems, Cretella stated.
"We found similar findings when the Lupron is used to treat certain gynecological issues in adult women," she added. "We have never had long-term studies on puberty blockers being used in biologically normal children. This is experimentation."
According to Cretella, puberty blockers can sometimes further "psychosocially isolate" children from their peers because they won't develop normally at a time when most of their classmates are. At such a point, Cretella says that children are put on cross-sex hormones.
"These [estrogen and testosterone] are serious drugs," she stressed. "Over the lifetime, they raise your risk of cardiovascular disease — cardiac arrest, stroke, diabetes, various cancers. These are not benign medications. And, they also can cause depression, anxiety. I thought [depression and anxiety] is what we wanted to treat. This is the standard of care now. It is not supported by science. It's ideology."
Hruz confirmed that it is "very-well known" that the risk for cardiovascular disease and stroke are "significantly increased" when people undergo cross-sex hormone treatment.
At about the age of 15, Cretella said that girls who wish to be males are cleared to have their breasts removed.
"The [American Academy of Pediatricians] isn't concerned with the increasing numbers of adult women who are coming out online ... saying, 'My physicians and therapists shepherded us along this path. They transitioned us to male. We now have no breasts, we are sterile because of puberty blockers,'" Cretella said. "They are waking up at age 28 or so and saying 'Oh my gosh, what was done to me?'"
Hruz argued that science demands that ideas that are put forward in medicine, such as gender transition treatments, need to be challenged scientifically. He contended that the drive of political activists to silence all who criticize hormone therapy and pubertal suppression treatments is "a threat to our practice of medicine and scientific integrity itself."
"For any investigator to put forward an alternative hypothesis to this current treatment paradigm is met with hostility," he said.