Defending Champions Manchester City host Everton who is fighting for a berth in next year's Champions League, while City look to remain the league's only unbeaten club this year.
Roberto Mancini and Manchester City will face a tough test at the Etihad Stadium on Saturday and will look to advance their current second place position in the league behind cross city rivals Manchester United.
Manchester City currently is just one point behind united and with nine wins and five draws have proven why they are a top club in the premiership.
Mancini will be without midfielder James Milner after the English international left with a hamstring injury soon after scoring during the midweek match at Wigan, but should be ready for the derby with Manchester United next week.
City will also be without midfielder Jack Rodwell and left-back Gael Clichy due to injury and right-back Micah Richards is also sidelined with a knee injury.
For manager David Moyes and Everton they are not only looking to secure full points from City, but are vying for a spot in the Champions League next year as they currently are in sixth place with 22 points, four behind fourth-place West Bromwich Albion.
Everton has earned their points with five wins, seven draws and two losses and like their counterparts today will have to start gaining full points if they hope to capture the fourth spot from West Brom.
Everton don't have a problem scoring goals with 24 for the season, but conceding 18 so far this year will not help them in their pursuit of a Champions League spot.
Everton will have to overcome some key injuries as Leighton Baines, Kevin Mirallas, Seamus Coleman and Phil Neville are all out with injury.
Kick-off for the match is at 10:00 a.m. ET and can be watched online here.