Arsenal will travel to Greece to finish off the group stage competition while looking to finish Group B in first place.
Arsenal and manager Arsene Wenger are hoping to finish Group B in first place and will do so if the Gunners win and Schalke fails to come away with points against Montpellier. Should Arsenal accomplish this feat, they will enter into the knockout stage of the competition as one of the seeded teams.
Wenger has faced tough criticism the past few weeks and angry fans will be louder than ever, given that the longtime manager has decided to leave several regular starters in England.
Theo Walcott, Lukas Podolski, Jack Wilshere, Santi Cazorla, Mikel Arteta and Per Mertesacker did not make the trip to Greece as they rest ahead of their league match with West Bromwich Albion on Saturday.
This match is a mere formality for both sides, as Arsenal has already secured a place in the next round and Olympiakos has already secured a place in the Europa League.
Wenger has faced criticism for his decision to rest his top players, but maintains that younger players rumored to start will gain valuable experience in this Champions League tie.
During a pre-match press conference, Wenger explained that playing football is not all about making headlines.
"You should look a little bit at the statistics and not only read the newspapers … I only have one pressure and that is to win the next football game and to play the football I love," Wenger said.
Some of Arsenal's young talent is expected start on Tuesday.
18-year-old forward Zak Ansah, 19-year-old Swiss defenders Sead Hajrovic and Elton Monteiro, as well as young English striker Chuba Akpom, 17, are all scheduled to make starts against Olympiakos at Georgios Karaiskakis Stadium.
While Olympiakos will be eliminated from the Champions League, they are playing well in their domestic league and are currently on a 13-match unbeaten streak in league play.
Kick-off for the match is at 2:45 ET and can be watched online here.