Manchester United make the trip to the Britannia Stadium in Sunday and are looking to recover from their recent defeat at the hands of cross town rivals Manchester City.
Even with that defeat United looked poised to capture the Premier League title given their current 12-point lead and Sir Alex Ferguson will look to have his team ready to snuff out any signs of a late season collapse.
Some point of concern for United may be the fact that Robin Van Persie has not scored for 10 games, keeping the Dutch striker stuck on 19 for the season. But he may be able to break that spell given that Stoke has never beaten United in the Premier League.
Some good news for United is that captain Nemanja Vidic returned to training on Friday after recovering from a calf injury and could be available for Sunday's match. Jonny Evans should also be available after recovering from the hamstring strain that has kept him out of the last two matches.
Stoke manager Tony Pulis and his side are on the opposite end of the football spectrum having been able to produce only one win and just five points in their last 13 Premier League matches.
Last weekend's 3-1 home defeat to Aston Villa left Stoke only three points above the relegation line, but since Wigan will be completing their FA Cup match this weekend, the Potters have the opportunity to increase the separation between themselves and relegation.
Pulis is a manager that has been under constant pressure this season and his side's record against United will not produce any extra confidence. Since promotion to the Premier League Stoke have earned only one point against United in nine games.
Kick-off for the match is at 9:05 a.m. ET and can be watched online here.