Grey's Anatomy Season 10 Spoilers: 'Circumstances This Season Are Devastating'

The season premiere of ABC hit medical drama "Grey's Anatomy" aired on Thursday, Sept. 26. The episode was full of action and drama, and seems to have raised just as many questions as it answered. Read on for what's to come in season 10, but be cautious of spoilers.

Season 10 contains the show's 200th episode. And executive producer Betsy Beers promises the celebratory episode will be filled with drama.

"I'm just going to say, if you're going to a fancy party on Grey's, you better watch yourself because you never know what's going to happen. There are some interesting combinations of people who are going to start to get together and get a little closer and it's a really, really different kind of party. You haven't seen a party like this before," Beers said.

Many fans are worried about the fate of Calizona, and actress Jessica Capshaw revealed that Calizona will eventually get better, but there is a hard road ahead.

The circumstances they've been dealt this season are devastating and there's really no way around that. So I think the best thing I can say is that they're going to deal with it on a very human and honest level," Capshaw told Entertainment Weekly.

Fans can also expect drama in Dr. Webber's plotline. Yes, he survived last season's ordeal, but now he has to recover.

"He's not going to be dealing with it well. This is a man who is very proud. This is a man who led people. He was a mentor, he was an administrator. When he walked by, folks hustled. When he barked, they listened. Now, he's a man who is in a bed and dependent on others," James Pickens, who plays Dr. Webber, explained to