Giuliana and Bill Rancic: 'Fingers Crossed' for Baby

Following this week's season premiere of "Giuliana & Bill," the Rancics have opened up about cancer and their persistent desire to start a family.

The first episode of reality show reveals Giuliana and Bill Rancic's personal struggles with behind-the scenes coverage of the issues that have made headlines.

Married for five years, the Rancics have coped with life-changing events in the past six months. In October, Giuliana announced that she had been diagnosed with an early stage of breast cancer.

She underwent a double lumpectomy and radiation treatments.

Additionally, the couple has publicly discussed their fertility issues on their reality television show as well as in interviews. After beginning in vitro fertilization (IVF), Giuliana became pregnant in March 2010, but suffered a miscarriage after nine weeks. A second attempt at IVF did not result in pregnancy.

Speaking about the television show which covered difficult parts of her life, Giuliana said she was advised to watch the episode ahead of its Tuesday air date.

"I watched it for the first time the other night, and it was hard to watch," the E! news anchor told The Hollywood Reporter.

"It's the first time that I haven't wanted to watch an episode, and I just didn't want to relive it."

The episode stirred painful recollections of the cancer diagnosis and struggles, but the 37-year-old said she wants "Giuliana & Bill" will remind women to think of their health.

"It [the show] is something that I hope women will be inspired by in terms of caring about themselves, putting themselves on their own to-do list, and really caring about their health," said Giuliana.

Her husband Bill added that as a couple they openly discuss things that many couples avoid talking about.

"If we can get one girl to go out and get a mammogram and get checked, then we did our job," Bill told THR. "So I'm very proud of it. I'm proud of Giuliana and it's definitely going to open up a lot of eyes."

Touching on whether or not they will continue to try starting a family together, Giuliana said, "Absolutely. Hopefully, this is our year."

"Fingers crossed," added Bill.

New episodes of "Giuliana & Bill" air Tuesdays at 8 p.m. EST on the Style Network.