Chelsea Handler lambasted CNN's Piers Morgan after hosting him on her show "Chelsea Lately" on Wednesday.
The two television personalities sparred on-air during the episode, resulting in Handler slamming her guest before he had even sat down on the set.
"What are you looking at," Handler asked Morgan.
Notoriously sharp-tongued Morgan responded with a back-handed compliment.
"Either you've had plastic surgery or a makeover as you really look hot today," the 47-year-old British journalist replied.
As the show continued, Handler said that Morgan had "molester eyes" and called the journalist "annoying."
"You are so annoying, you are so obnoxious and you wonder why everyone hates you," 37-year-old Handler told Morgan.
The former newspaper editor fired back, telling Handler, "Normally when I come on the show you are really hungover in a really unprofessional way," before turning to the audience and adding, "She's like a bad boomerang, you chuck her away and she just sucks back in."
Morgan's appearance on "Lately" marked his 2-year anniversary on CNN with his show Piers Morgan Tonight," and his second time on Handler's show.
"You interviewed me last year on my first anniversary and it just proves one thing," started Morgan when Handler interrupted him.
"Let me guess," said the blonde book author. "That you're a better interviewer than I am?"
Handler went on to explain that she does not pretend to be a superior presenter.
"I don't even pretend to be good at my job," she defended.
Morgan then chortled, "That's clearly apparent today but I can help you."
Clearly outraged, Handler turned to profanity, demanding that Morgan "suck her a--." Watch the awkward interaction here.
Meanwhile, Morgan is the author of eight books, including three volumes of memoirs. The Guildford, Surrey, England native has experiences several other feuds in the past, including with fellow British journalist Ian Hislop, television personality Jeremy Clarkson, and Madonna.
Furthermore, Morgan once tweeted the British actor Hugh Grant was banned from his show.
"Hugh Grant is now banned, in perpetuity, from PiersTonight… and anything else I ever do. Tedious little man," the television host posted to Twitter.
Alternately, Handler is a comedian, actress, and author in addition to hosting her own late-night talk show.