1894 - 121 Seats (116 House, 5 Senate)
President Grover Cleveland was in the White House for what History.com once labeled the "Biggest Landslide in Midterm Election History."
In total, President Cleveland's Democrats lost 116 seats in the House of Representatives and 5 seats in the Senate, Republicans taking control due in large part to a crippling recession.
"Almost 90 percent of northeastern and Midwestern House Democrats lost re-election. Even in the Deep South, a bastion of Democratic support since the Civil War, seats were lost in four states," noted History.com.
"In total, Democrats lost 116 seats in the House and five in the Senate. This was made all the worse, by today's standards, because there were only 44 states in the Union."